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KMID : 0381919990290020137
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Korean Journal of Microscopy
1999 Volume.29 No. 2 p.137 ~ p.147
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Formation of Metastases in C57 BL/6 Mouse Lung
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Kim Ji-Hyun
Lee Ji-Young
Kim Woo-Kab
Hwang Woo-Ik
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Abstract
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Comparative differences between the fine structure of cultured LL/2 cell in vitro and tumor cells in vivo which were induced in the lung by inoculation of LL/2 cells to C57 BL/6 mouse via tail vein during 21 days are not observed except for cell configuration which was changed spindle shape into oval shape. At first tumor cells appeared at lymphatic nodules and around capillary in the lung. Tumor cells divided actively by mitosis, so they became tumor nodules. The pulmonary aveoli around tumor nodules were observed somewhat flattened in shape but the cells in the aveoli appeared to be in normal condition. Furthermore the normal lung cells were observed in the tumor nodules and some apoptotic tumor cells appeared in the large tumor nodules. A lot of neutropiles were observed in the aveoli and tumor nodules of C57 BL/6 mouse lung after inoculation 22 days and 31days.
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KEYWORD
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C57 BL/6 mouse, Tumor cell, Metastasis, Lung
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